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KMID : 1134220080280040016
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Hanyang Medical Reviews
2008 Volume.28 No. 4 p.16 ~ p.21
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KATP channel
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Hong Deok-Man
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Abstract
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Pharmacological preconditioning with volatile anesthetics is a phenomenon whereby a brief exposure to volatile anesthetic agents protects the heart from the potentially fatal consequences of a subsequent prolonged period of myocardial
ischemia and reperfusion. Although not completely elucidated, the cellular and molecular mechanisms of pharmacological preconditioning appear to mimic those of ischemic preconditioning, the most powerful endogenous cardioprotective
mechanism. Activation of ATP-dependent potassium (KATP) channels in the myocardium plays an important cardioprotective role during ischemia. This article reviews current concepts and controversies regarding the specific roles of the mitochondrial and the sarcolemmal KATP channels in pharmacological preconditioning by volatile anesthetics.
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KEYWORD
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KATP channel, Volatile anesthetics, Preconditioning, Myocardial protection
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